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“The close collaboration between scientists and clinicians has been the primary motivation for joining the Tisch MSRCNY. The daily interaction with patients is a constant reminder that our ultimate goal is translating scientific discoveries into novel therapeutic interventions that will prevent MS progression.”
- Dr. Anna Iacoangeli, Assistant Research Scientist
Dr. Iacoangeli joined the Tisch MS Research Center scientific team in March 2017. Prior to her appointment at the Center, she served as a Research Assistant Professor at SUNY Downstate Medical Center in Brooklyn. Dr. Iacoangeli‘s research interests have focused on understanding the molecular functions of a subtype of regulatory non-coding RNAs (ncRNAs) in neuronal processes and mechanisms. She recently published that dysregulation of these RNAs at synapses resulted in cognitive impairment. In her clinical research at SUNY Downstate, Dr. Iacoangeli identified a novel RNA-based biomarker for invasive breast cancer diagnosis and prognosis.
At the Tisch MS Research Center, Dr. Iacoangeli’s research emphasis is on investigating how regulatory ncRNAs contribute to the biochemical and cellular mechanisms leading to multiple sclerosis (MS) onset and progression. With state-of-the-art approaches, Dr. Iacoangeli aims to establish relevant ncRNAs as therapeutic candidates for the treatment of MS. Furthermore, Dr. Iacoangeli is studying severe cognitive dysfunction in MS. More than half of MS patients will experience cognitive disorders during their disease course. Substantial cognitive decline, affecting memory and executive functions, results in social and occupational impairment. Understanding the underlying causes of cognitive dysfunction in MS patients will translate into effective and tailored treatment strategies.
Dr. Iacoangeli received her Ph.D. in Applied Genetics and her Master in Biological Sciences from the Department of Genetics and Molecular Biology “Charles Darwin”, at the Sapienza University of Rome, Italy.
Dr. Iacoangeli works with research assistant, Natalie Favret (BA from Wesleyan University '17).