Tamara Vyshkina, PhD

"For me, connecting with a patient story has been the driving force behind my stem cell research. Working at the Tisch MS Research Center has a meaningful impact both personally and professionally."

 - Dr. Tamara Vyshkina, Assistant Research Scientist

Dr. Vyshkina currently works in Dr. Harris’ team studying therapeutic use of bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) as a strategy for repair and regeneration in MS. Dr. Vyshkina has developed cell culture and quality control procedures for the growth, differentiation, and characterization of autologous MSC-NPs from MS patients, as described in recent publications.

Dr. Vyshkina received her PhD in Chemistry from Kiev State University, Ukraine, and her MS in Biophysics from Moscow State University, Russia. From 2003 to 2006 she worked at the MS Research & Treatment Center at Roosevelt Hospital. Her research was in the field of statistical genetics, investigating the role of CC chemokine ligands and Complex I genes in multiple sclerosis and association of marker haplotypes within chromosome 17q11 region with the disease in family-based and case-control studies. In 2001-2003 she was a postdoctoral fellow at the Department of Biochemistry and Molecular Biology at College of Medicine, Pennsylvania State University.

Additional published research includes:
Kumagai C, Kalman B, Middleton FA, Vyshkina T., Massa PT. Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects. Journal of Neuroimmunology 2012; 246(1-2):51-57.
Blokhin A., Vyshkina T., Komoly S., Kalman B. Variations in mitochondrial DNA copy numbers in MS brains. Journal of Molecular Neuroscience 2008; 35(3): 283-287.
Vyshkina T., Kalman B. Auto-antibodies and neurodegeneration in multiple sclerosis. Laboratory Investigation 2008; 88(8): 796-807.
Blokhin A., Vyshkina T., Komoly S., Kalman B. Lack of mitochondrial DNA deletions in lesions of multiple sclerosis. Neuromolecular Medicine 2008; 10(3): 187-194.
Vyshkina T., Kalman B. Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis. Multiple sclerosis, 14(4): 433-439.
Vyshkina T., Kalman B. Analyses of a MS-associated haplotypes encompassing the CCL3 gene. J Neuroimmunology 2006; 176: 216-218.
Vyshkina T., Kalman B. Haplotypes within genes of β-chemokines in 17q11 are associated with multiple sclerosis: a second phase study. Human Genetics  2005; 118: 67-75.
Vyshkina T., Shugart Y.Y., Birnbaum G., Leist T.P., Kalman B.: Association of haplotypes in the beta-chemokine locus with multiple sclerosis.  Eur J Hum Genet  2005, Feb; 13(2): 240-247.
Vyshkina T., Banisor I., Shugart Y.Y., Leist T.P., Kalman B.: Genetic variants of Complex I in multiple sclerosis.  J Neurol Sci  2005; 228(1): 55-64.
Vyshkina T., Leist T.P., Shugart Y.Y., Kalman B.: CD45 (PTPRC) as a candidate gene in multiple sclerosis.  Multiple Sclerosis 2004; 10: 614-617.

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