Safety of long-term intrathecal methotrexate in progressive forms of MS

Publication Date

December 3, 2019

Publication Information

Stark J, Josephs L, Dulak D, Clague M, and Sadiq SA. Therapeutic Advances in Neurological Disorders. 2019; 12: 1756286419892360.

There are few treatment options for multiple sclerosis (MS) patients with advanced disability [expanded disability status scale (EDSS) ⩾ 6.0]. In 2010, we reported initial results of using intrathecal methotrexate (ITMTX) in patients with progressive MS. We now report on long-term use of ITMTX. We performed a retrospective chart analysis of patients who have had 18 or more treatments to establish the ongoing safety and tolerability of ITMTX. Thus, the objective of this study was to establish the safety and tolerability of long-term therapy with (ITMTX) in patients with treatment-resistant, progressive forms of MS.

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